We have had an internal timesheeting system written in Access services running without any problems for the past through months. At the end of last week, when people tried to submit their timesheets they started getting a -4002 error saying the macro (that saves the weekly sheet) could not be started.
Checking the server event logs, Sharepoint logs and Access services log tables showed nothing. So as all good IT staff do we tried the traditional IISRESET command (on both our Sharepoint web servers) and it all leapt back into life. The only change on our server in the past week has been been the ASP.NET security fix, and associated reboot, but I cannot see why this should effect Access Services, it looked as if it had basically Access services just failed to restart fully after the server reboot.
One to keep an eye on.